To give mezcal a pleasant bitterness, bartender Jeremy Oertel stirs in grapefruit liqueur. The bracing bitterness of Campari emphasizes the grapefruit flavor. Slideshow: Mezcal Cocktail RecipesRecipe from Food & Wine Cocktails 2015
In a mixing glass, combine the mezcal, grapefruit liqueur, vermouth and Campari. Fill the glass with ice, stir well and strain into a chilled martini glass or coupe. Pinch the grapefruit twist over the drink and discard.