Smoky mezcal brings depth to a classic margarita. A combination of slightly sweeter Combier and mildly bitter Cointreau balances the floral orange notes in the drink. Double the Cointreau if Combier is unavailable.
Combine mezcal, lime juice, Combier, and Cointreau in a cocktail shaker. Fill with ice cubes; cover and shake until shaker is frosty, about 30 seconds. Rub half of glass rim with lime peel; dip in salt. Fill glass with ice; strain margarita into glass. Garnish with lime wedge.