Why go: Prague offers a tableau of red-tiled roofs, fairytale castles and architectural styles that encompass everything from Renaissance to Cubist. And thanks to an increasingly modern sensibility, the Czech capital also has innovative restaurants, hotels and shops.
Where to stay: A restored Art Deco building in the city's center, Hotel Imperial has marble bathrooms and custom-designed wooden furniture. Rooms from around $140; hotel-imperial.cz.
Where to eat: Occupying the top two floors of Frank Gehry's Dancing House, Celeste serves a seafood-heavy menu cooked by an Alain Ducasse alum.