Why go: Gorgeous vistas, dizzying hills and pretty row houses make San Francisco one of the most romantic cities in the United States. There’s artisanal food everywhere, from fair-trade coffee shops to the incomparable Ferry Building farmers’ market.
Where to stay: Located in a landmark building where part of Alfred Hitchcock's Vertigo was shot, Hotel Vertigo draws film buffs. Design buffs love the bold orange-and-white color scheme. Rooms from $99; hotelvertigosf.com.
Where to eat: At Cotogna, Michael Tusk updates rustic Italian cuisine with dishes like roast lamb with sunchokes and bagna cauda, and house-made tortelloni with rutabaga and pine nuts.