Why go: In Istanbul, new art galleries, boutiques and nightclubs pop up next to gorgeous Ottoman mosques and tea gardens. It’s an intoxicating mix that makes the legendary Turkish destination deserving of its nickname, the City of the World's Desire.
Where to stay: A four-story mansion built in the 1890s, the House Hotel Galatasaray has elegant rooms and a top-floor breakfast lounge where eggs are cooked to order. Rooms from about $135; thehousehotel.com.
Where to eat: Tucked into a 1920s house, Balikçi Sabahattin has impeccably fresh meze and seafood; nearby, tiny Rumeli is a must for baklava.