The world's most popular grapes, like Cabernet Sauvignon, have become global varietals. But today, many overlooked indigenous grapes (those native to the place they’re grown) are being made into world-class wines. Some examples are Italy's Nero d'Avola and Spain's Albariño. For something more obscure but equally delicious, try the 2008 Ajello Grillo-Catarratto, a blend of two indigenous white grape varieties from Sicily.
Pairing: Grilled swordfish, which is excellent with this fish-friendly white.