Preheat the oven to 375°. In a medium saucepan, combine the water, butter, wine, salt and pepper and bring to a boil over moderate heat. Add the flour all at once and beat with a wooden spoon until the dough is smooth and gathers into a ball, about 1 minute. Remove from the heat and let stand until cooled slightly, about 5 minutes. Beat in 1 egg at a time, beating until the dough is smooth and slightly sticky between additions. Stir in the Gruyère.
Fit a pastry bag with a 1/2-inch tip and fill the bag with the dough. Pipe 1-inch mounds of the dough onto 2 parchment paper–lined baking sheets. Bake for about 30 minutes, until the cheese puffs are golden, rotating the baking sheets halfway through. Serve warm.
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