Alessandro Bisceglie and Elyssa Bernard opened the three-room Daphne Inn in 2001. Since then, the chic guesthouse has expanded to 15 rooms in two palazzi near the Via Veneto. Details include Bisazza mosaics on the walls and offbeat artworks hanging above the beds. Each room comes with a cell phone for calling the staff. Although Nos. 222 and 223 are the most affordable rooms, they lack private bathrooms.