Hoteliers Sean MacPherson and Eric Goode—the team behind New York’s Maritime Hotel—are breathing new life into Manhattan’s once-desolate Bowery with their 135-room Bowery Hotel. Entering the lobby is like stepping into a pre-Raphaelite painting: a Gothic fireplace, Oriental rugs over a Moroccan-tiled floor. Rooms are pure vintage-repro, down to the beadboard ceilings; toiletries from the storied Bigelow & Co. Apothecary line marble washstands. Those expecting a dose of New York attitude will be disappointed by the friendly staff. There’s plenty of native flavor, however, at the Italian restaurant, Gemma, where focaccia-bread pizzas are drizzled with truffle oil, and the bar is reliably thronged by those city denizens known as Beautiful People. Work it off with a bike ride on one of the hotel's four lipstick-red Earth Cruisers, equipped with wire baskets to hold your shopping finds.