Maybe it’s all the grain, or the football, or the wholesome appreciation for life’s best things—whatever the reason, the Midwest is home to some of America’s best breweries. This is not news; beer lovers drool over many of the region’s ales, even if they’ve never made the trek to the area. But hey: modern roadways allow for easy weekend trips to these brewpubs (provided you buckle up and designate a driver.) Below, check out some of the greatest breweries east of the Mississippi. —Claire Luchette

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