Could there possibly be a single secret left in Venice, the world's most touristed city? The famous Prosecco-making Bisol family has found one. In restoring a 19th-century manor and vineyard on Mazzorbo island to create a new inn, Venissa, they stumbled upon a white-grape varietal, Dorona, once thought extinct. Guest rooms at Venissa are spare and chic; its restaurant uses local ingredients, including alpago, a rare native breed of lamb.
The Venissa is a great home base for travelers who want to make some discoveries of their own. A wooden footbridge from Mazzorbo connects to the island of Burano for Venice's best spider crab, at Riva Rosa.